Ikramuddin Aukhil, BDS, MS

Associate Dean for Faculty Affairs
Professor, Department of Surgical Sciences

aukhili23@ecu.edu
252-737-7856
4126 Ledyard E. Ross Hall

Education

BDS – Bangalore University, India
MS – Periodontology, University of Michigan

Clinical/Research Interests

Wound Healing, Tissue Regeneration, Extracellular Matrix Biology & Molecular Biology of inflammation.

Society Memberships

American Dental Association
International Association of Dental Research
American Academy of Periodontology
American Association for Advancement of Science
American Society for Cell Biology

Biographical Information

Dr. Ikramuddin Aukhil earned his dental degree from Bangalore University in Karnataka, India. He emigrated to the United States in 1978 and started his residency training in Periodontology at the University of Michigan in Ann Arbor under the mentorship of Dr. Sigurd Ramfjord. Soon after completing his training, he was appointed Assistant Professor in the Department of Periodontology at the U.N.C. School of Dentistry where he quickly rose through the ranks to become tenured Professor in 1994. In 1988-89, he was awarded the Kenan Leave for a year that he spent in the Department of Cell Biology at Duke University under the mentorship of Dr. Harold P. Erickson. Dr. Aukhil was named Professor & Chair of the Department of Periodontology at the University of Florida, Gainesville in 2005 and he remained in that position till Sept. 2022. Dr. Aukhil retired from University of Florida (UF) in Feb. 2023 and he continues to hold Professor Emeritus status at UF. He joined ECU as Associate Dean for Faculty Affairs and Professor in the Department of Surgical Sciences Feb. 2023. Throughout his academic career, he continued participating in the Faculty Practice one day a week (UNC, UF). He has been the recipient of several RO1 Research Grants from NIDCR, from 1983 till 2019 along with some industrial contracts to support his research. He has served on NIH study sections and published numerous articles in peer-reviewed journals. He has also served on many important committees at both UNC and UF.

Publications

For full listing visit: https://pubmed.ncbi.nlm.nih.gov/?term=Aukhil,I.

H. Huang, J. Lu, I. Aukhil, et al., FBXO11 regulates bone development, Bone (2023), https://doi.org/10.1016/j.bone.2023.116709

Aukhil I. Biology of wound healing. Periodontol 2000. 2000 Feb;22:44-50. doi: 10.1034/j.1600-0757.2000.2220104.x. PMID: 11276515.

Tabaa M, Adatowovor R, Shabila A, Morford L, Harrison P, Aukhil I, Huang H, Stromberg A, Goncalves J, Shaddox L. Pattern of grade C molar-incisor pattern periodontitis in families. J Periodontol. 2022 Nov 12. doi: 10.1002/JPER.22-0317. Epub ahead of print. PMID: 36370032.

Gonçalves PF, Harris TH, Elmariah T, Aukhil I, Wallace MR, Shaddox LM. Genetic polymorphisms and periodontal disease in populations of African descent: A review. J Periodontal Res. 2018 Apr;53(2):164-173. doi: 10.1111/jre.12505. PMID: 29105764; PMCID: PMC5912940.

Tavakoli TT, Gholami F, Huang H, Gonçalves PF, Villasante-Tezanos A, Aukhil I, de Oliveira RCG, Hovencamp N, Wallet S, Ioannidou E, Shaddox LM. Gender differences in immunological response of African-American juveniles with Grade C molar incisor pattern periodontitis. J Periodontol. 2022 Mar;93(3):392-402. doi: 10.1002/JPER.21-0143. PMID: 34173226; PMCID: PMC8709874.

Gonçalves Fernandes J, Morford LA, Harrison PL, Kompotiati T, Huang H, Aukhil I, Wallet SM, Macchion Shaddox L. Dysregulation of genes and microRNAs in localized aggressive periodontitis. J Clin Periodontol. 2020 Nov;47(11):1317-1325. doi: 10.1111/jcpe.13361. PMID: 32876337.

Shaddox L, Wiedey J, Bimstein E, Magnuson I, Clare-Salzler M, Aukhil I, Wallet SM. Hyper-responsive phenotype in localized aggressive periodontitis. J Dent Res. 2010 Feb;89(2):143-8. doi: 10.1177/0022034509353397. PMID: 20042739; PMCID: PMC3096871.

Harris TH, Wallace MR, Huang H, Li H, Mohiuddeen A, Gong Y, Kompotiati T, Harrison P, Aukhil I, Shaddox LM. Association of P2RX7 functional variants with localized aggressive periodontitis. J Periodontal Res. 2020 Jan;55(1):32-40. doi: 10.1111/jre.12682. PMID: 31292966; PMCID: PMC8018522.

Branco-de-Almeida LS, Cruz-Almeida Y, Gonzalez-Marrero Y, Kudsi R, de Oliveira ICV, Dolia B, Huang H, Aukhil I, Harrison P, Shaddox LM. Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation. J Clin Periodontol. 2021 Feb;48(2):237-248. doi: 10.1111/jcpe.13404 PMID: 33205510; PMCID: PMC7825363.

Hakam AE, Vila G, Duarte PM, Mbadu MP, Ai Angary DS, Shuwaikan H, Aukhil I, Neiva R, da Silva HDP, Chang J. Effects of different antidepressant classes on dental implant failure: A retrospective clinical study. J Periodontol. 2021 Feb;92(2):196-204. doi: 10.1002/JPER.19-0714. PMID: 32725908.

Shaddox LM, Mullersman AF, Huang H, Wallet SM, Langaee T, Aukhil I. Epigenetic regulation of inflammation in localized aggressive periodontitis. Clin Epigenetics. 2017 Sep 2;9:94. doi: 10.1186/s13148-017-0385-8. PMID: 28883894; PMCID: PMC5581417.

Shaddox LM, Huang H, Lin T, Hou W, Harrison PL, Aukhil I, Walker CB, Klepac-Ceraj V, Paster BJ. Microbiological characterization in children with aggressive periodontitis. J Dent Res. 2012 Oct;91(10):927-33. doi:
10.1177/0022034512456039. PMID: 22863892; PMCID: PMC3446830.

Branco-de-Almeida LS, Cruz-Almeida Y, Gonzalez-Marrero Y, Huang H, Aukhil I, Harrison P, Wallet SM, Shaddox LM. Local and Plasma Biomarker Profiles in Localized Aggressive Periodontitis. JDR Clin Trans Res. 2017 Jul;2(3):258-268. doi: 10.1177/2380084417701898. PMID: 28879248; PMCID: PMC5576058.

Shaddox LM, Gonçalves PF, Vovk A, Allin N, Huang H, Hou W, Aukhil I, Wallet SM. LPS-induced inflammatory response after therapy of aggressive periodontitis. J Dent Res. 2013 Aug;92(8):702-8. doi: 10.1177/0022034513495242.

Bencharit S, Cui CB, Siddiqui A, Howard-Williams EL, Sondek J, Zuobi-Hasona K, Aukhil I. Structural insights into fibronectin type III domain-mediated signaling. J Mol Biol. 2007 Mar 23;367(2):303-9. doi: 10.1016/j.jmb.2006.10.017. Oct 11. PMID: 17261313; PMCID: PMC2583400.

Shaddox LM, Spencer WP, Velsko IM, Al-Kassab H, Huang H, Calderon N, Aukhil I, Wallet SM. Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque. J Clin Periodontol. 2016 Sep;43(9):746-53. doi: 10.1111/jcpe.12560. PMID: 27037664; PMCID: PMC4975966.

Cui CB, Cooper LF, Yang X, Karsenty G, Aukhil I. Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ. Mol Cell Biol. 2003 Feb;23(3):1004-13. doi: 10.1128/MCB.23.3.1004-1013.2003. PMID: 12529404; PMCID: PMC140696.

Aukhil I, Nishimura K, Fernyhough W. Experimental regeneration of the periodontium. Crit Rev Oral Biol Med. 1990;1(2):101-15. doi: 10.1177/10454411900010020101. PMID: 2129620.

Mesia R, Gholami F, Huang H, Clare-Salzler M, Aukhil I, Wallet SM, Shaddox LM. Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis. BMJ Open Diabetes Res Care. 2016 Sep 8;4(1):e000260. doi: 10.1136/bmjdrc-2016-000260. PMID: 27651910; PMCID: PMC5020743.

Aukhil I, Iglhaut J. Periodontal ligament cell kinetics following experimental regenerative procedures. J Clin Periodontol. 1988 Jul;15(6):374-82. doi: 10.1111/j.1600-051x.1988.tb01015.x. PMID: 3165397.

Iglhaut J, Aukhil I, Simpson DM, Johnston MC, Koch G. Progenitor cell kinetics during guided tissue regeneration in experimental periodontal wounds. J Periodontal Res. 1988 Mar;23(2):107-17. doi: 10.1111/j.1600-0765.1988.tb01342.x. PMID: 2967362.

Murphy-Ullrich JE, Lightner VA, Aukhil I, Yan YZ, Erickson HP, Höök M. Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. J Cell Biol. 1991 Nov;115(4):1127-36. doi: 10.1083/jcb.115.4.1127.. PMID: 1720121; PMCID: PMC2289958.

Aukhil I, Joshi P, Yan Y, Erickson HP. Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. J Biol Chem. 1993 Feb 5;268(4):2542-53. PMID: 7679097.

Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP. Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science. 1992 Nov 6;258(5084):987-91. doi: 10.1126/science.1279805. PMID: 1279805.

Leahy DJ, Aukhil I, Erickson HP. 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell. 1996 Jan 12;84(1):155-64. doi: 10.1016/s0092-8674(00)81002-8. PMID: 8548820.

Hashimoto-Uoshima M, Yan YZ, Schneider G, Aukhil I. The alternatively spliced domains EIIIB and EIIIA of human fibronectin affect cell adhesion and spreading. J Cell Sci. 1997 Sep;110 ( Pt 18):2271-80. doi: 10.1242/jcs.110.18.2271. PMID: 9378776.

De Kok IJ, Peter SJ, Archambault M, van den Bos C, Kadiyala S, Aukhil I, Cooper LF. Investigation of allogeneic mesenchymal stem cell-based alveolar bone formation: preliminary findings. Clin Oral Implants Res. 2003 Aug;14(4):481-9. doi: 10.1034/j.1600-0501.2003.110770.x. PMID: 12869011.

Velsko IM, Chukkapalli SS, Rivera-Kweh MF, Zheng D, Aukhil I, Lucas AR, Larjava H, Kesavalu L. Periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice. Infect Immun. 2015 Dec;83(12):4582-93. doi: 10.1128/IAI.01077-15. Epub 2015 Sep 14. PMID: 26371120; PMCID: PMC4645375.

Aukhil I, Simpson DM, Schaberg TV. An experimental study of new attachment procedure in beagle dogs. J Periodontal Res. 1983 Nov;18(6):643-54. doi: 10.1111/j.1600-0765.1983.tb00401.x. PMID: 6230436.

Aukhil I, Pettersson E, Suggs C. Guided tissue regeneration. An experimental procedure in beagle dogs. J Periodontol. 1986 Dec;57(12):727-34. doi: 10.1902/jop.1986.57.12.727. PMID: 3467057.

Aukhil I, Simpson DM, Suggs C, Pettersson E. In vivo differentiation of progenitor cells of the periodontal ligament. An experimental study using physical barriers. J Clin Periodontol. 1986 Oct;13(9):862-8. doi: 10.1111/j.1600-051x.1986.tb02244.x. PMID: 3465757.

Lin TH, Aplin AE, Shen Y, Chen Q, Schaller M, Romer L, Aukhil I, Juliano RL. Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J Cell Biol. 1997 Mar 24;136(6):1385-95. doi: 10.1083/jcb.136.6.1385. PMID: 9087451; PMCID: PMC2132513.

Knox B, Aukhil I. Ultrastructural study of experimental cementum regeneration in rats. J Periodontal Res. 1988 Jan;23(1):60-7. doi: 10.1111/j.1600-0765.1988.tb01028.x. PMID: 2963905.